Related work has been done in non-human primates. For a small study in Brain and Behavioral Research, researchers removed the ovaries of some Japanese macaques at a National Primate Research Center in Beaverton, Ore., where hundreds of females live in close contact with their mothers, grandmothers, sisters, and female cousins. Researchers reasoned these snow monkeys could model mood changes due to ovariectomy without confounding variables like the social stigma of barrenness that might affect women. The center picked 10 females of equivalent rank in the dominance hierarchies and removed the ovaries and uterus from five of them. The other five had their ?tubes tied,? so were sterile but still had intact ovaries. Since the monkeys wouldn?t understand the biological ramifications of surgery, and would have similar social lives, any difference between the two groups could be attributed to ovarian hormones.
Source: http://feeds.slate.com/click.phdo?i=bad6fa7db07facc2e55efae415c14d64
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